Inflammatory Bowel Disease Definition Idiopathic disorder Composed of Two presentation C rohn’s Disease and Ulcerative colitis , both distinct and overlapping pathologic and clinical characteristics. Epidemiology

Inflammatory Bowel Disease Definition Idiopathic disorder Composed of Two presentation C rohn’s Disease and Ulcerative colitis , both distinct and overlapping pathologic and clinical characteristics. Epidemiology: ● More common in the west and developed countries such as Canada ● More common in Caucasians than other racial groups. ● Mean age (peak) is 15 to 35 years, and there is second peak at age of 50. Etiology: Both diseases has no clear cause, but there multiple factors which hypothesized to Play Role: 1- Environmental factors ● Smoking : increase a chance crohn’s disease and seen to have a protected role in Ulcerative colitis. ● Appendectomy is seen to have a protected role in Ulcerative colitis ● Persistent infection ● Defective mucosal integrity: because it leads increase susceptibility of antigen to go from gut into blood which → autoimmune response ● Dysbiosis (change in microbiota of the gut) . I ● Dysregulated immune response 2-Diet : Western diet and Frozen food increase a chance of IBD especially in child before 10 years 3-Genetic factors: NOD2/CARD15 increase a chance of IBD and it’s mainly found in